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MYH9 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: actin cytoskeleton; actomyosin; actomyosin contractile ring; brush border; cell leading edge; cell-cell adherens junction; cleavage furrow; cytoplasm; cytosol; extracellular matrix; focal adhesion; immunological synapse; integrin complex; membrane; myosin II complex; neuromuscular junction; nucleus; plasma membrane; protein complex; ruffle; signalosome; spindle; stress fiber; uropod
Molecular Function: actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; cadherin binding; calmodulin binding; microfilament motor activity; motor activity; protein anchor; protein binding; protein domain specific binding; protein homodimerization activity; RNA binding
Biological Process: actin cytoskeleton reorganization; actin filament-based movement; actomyosin structure organization; angiogenesis; blood vessel endothelial cell migration; cytokinetic process; establishment of meiotic spindle localization; establishment of T cell polarity; in utero embryonic development; integrin-mediated signaling pathway; leukocyte migration; meiotic spindle organization; membrane protein ectodomain proteolysis; monocyte differentiation; myoblast fusion; phagocytosis, engulfment; platelet formation; protein transport; regulation of cell shape; uropod organization
Disease: Deafness, Autosomal Dominant 17; Epstein Syndrome; Fechtner Syndrome; Macrothrombocytopenia And Progressive Sensorineural Deafness; May-hegglin Anomaly; Sebastian Syndrome
Reference #:  P35579 (UniProtKB)
Alt. Names/Synonyms: Cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MGC104539; MHA; MYH9; MYH9 variant protein; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; Myosin-9; NMHC-II-A; NMMHC II-a; NMMHC-A; NMMHC-IIA; NMMHCA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Gene Symbols: MYH9
Molecular weight: 226,532 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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