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GPR183 Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Signals constitutively through G(i)-alpha, but not throughG(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13q32.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; oxysterol binding
Biological Process: adaptive immune response; B cell activation during immune response; dendritic cell chemotaxis; G-protein coupled receptor protein signaling pathway; humoral immune response; immune response; leukocyte chemotaxis; mature B cell differentiation during immune response; osteoclast differentiation; positive regulation of B cell proliferation
Reference #:  P32249 (UniProtKB)
Alt. Names/Synonyms: EBI2; EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; G-protein coupled receptor 183; GP183; GPR183
Gene Symbols: GPR183
Molecular weight: 41,224 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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