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DLL3 Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: integral component of membrane
Molecular Function: calcium ion binding; Notch binding
Biological Process: compartment pattern specification; negative regulation of neurogenesis; Notch signaling pathway; paraxial mesoderm development; skeletal system development; somitogenesis
Disease: Spondylocostal Dysostosis 1, Autosomal Recessive
Reference #:  Q9NYJ7 (UniProtKB)
Alt. Names/Synonyms: delta-like 3 (Drosophila); Delta-like protein 3; Delta3; DLL3; Drosophila Delta homolog 3; SCDO1
Gene Symbols: DLL3
Molecular weight: 64,618 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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