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P2RY5 Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 with or without hypotrichosis (ARWH1). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Defects in LPAR6 are the cause of hypotrichosis type 8 (HYPT8). A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13q14.2
Cellular Component: integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane
Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of Rho protein signal transduction
Disease: Hypotrichosis 8
Reference #:  P43657 (UniProtKB)
Alt. Names/Synonyms: G-protein coupled purinergic receptor P2Y5; LAH3; LPA receptor 6; LPA-6; LPAR6; Lysophosphatidic acid receptor 6; MGC120358; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2RY5; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; purinergic receptor P2Y, G-protein coupled, 5; RB intron encoded G-protein coupled receptor
Gene Symbols: LPAR6
Molecular weight: 39,392 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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