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NPY2R Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component: integral component of plasma membrane; intracellular; plasma membrane
Molecular Function: calcium channel regulator activity; neuropeptide Y receptor activity; peptide YY receptor activity; protein binding; receptor activity
Biological Process: aging; behavioral fear response; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; locomotory behavior; negative regulation of cAMP biosynthetic process; negative regulation of neurological process; negative regulation of secretion; negative regulation of synaptic transmission, glutamatergic; neuropeptide signaling pathway; nitric oxide mediated signal transduction; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of molecular function; regulation of sensory perception of pain; secretion; synaptic transmission
Reference #:  P49146 (UniProtKB)
Alt. Names/Synonyms: Neuropeptide Y receptor type 2; neuropeptide Y receptor Y2; NPY-Y2 receptor; NPY2-R; NPY2R; Y2 receptor
Gene Symbols: NPY2R
Molecular weight: 42,731 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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