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HEPH May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: X C3|X 42.69 cM
Cellular Component: basolateral plasma membrane; integral component of membrane; intracellular; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: copper ion binding; ferrous iron binding; ferroxidase activity; metal ion binding; oxidoreductase activity
Biological Process: cellular iron ion homeostasis; copper ion transport; erythrocyte differentiation; ion transport; iron ion homeostasis; iron ion transport; transport
Reference #:  Q9Z0Z4 (UniProtKB)
Alt. Names/Synonyms: C130006F04Rik; Cpl; haphaestin; Heph; Hephaestin; Kiaa0698; mKIAA0698; sex linked anemia; sla
Gene Symbols: Heph
Molecular weight: 129,666 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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