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USP36 May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component: nuclear speck; nucleolus; nucleus
Molecular Function: cysteine-type peptidase activity; hydrolase activity; peptidase activity; RNA binding; thiol-dependent ubiquitin-specific protease activity
Biological Process: protein deubiquitination; proteolysis; ubiquitin-dependent protein catabolic process
Reference #:  B1AQJ2 (UniProtKB)
Alt. Names/Synonyms: 2700002L06Rik; Deubiquitinating enzyme 36; Kiaa1453; mKIAA1453; Ubiquitin carboxyl-terminal hydrolase 36; ubiquitin specific peptidase 36; ubiquitin specific protease 36; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36; UBP36; Usp36
Gene Symbols: Usp36
Molecular weight: 119,913 Da
Basal Isoelectric point: 9.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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