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TGM1 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Note: This description may include information from UniProtKB.
Protein type: EC; Transferase
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cornified envelope; cytosol; intrinsic component of membrane; plasma membrane
Molecular Function: metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity
Biological Process: cell envelope organization and biogenesis; cellular protein modification process; keratinocyte differentiation; peptide cross-linking; positive regulation of cell cycle
Disease: Ichthyosis, Congenital, Autosomal Recessive 1
Reference #:  P22735 (UniProtKB)
Alt. Names/Synonyms: Epidermal TGase; ICR2; KTG; LI; LI1; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGASE; TGase K; TGase-1; TGK; TGM1; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Transglutaminase K; transglutaminase, keratinocyte; Transglutaminase-1
Gene Symbols: TGM1
Molecular weight: 89,787 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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