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IL8RB Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cell surface; integral component of plasma membrane; intracellular; mast cell granule; membrane; plasma membrane; secretory granule membrane
Molecular Function: C-X-C chemokine receptor activity; interleukin-8 binding; interleukin-8 receptor activity; protein binding; signal transducer activity
Biological Process: cell surface receptor signaling pathway; cellular defense response; chemotaxis; dendritic cell chemotaxis; G-protein coupled receptor signaling pathway; inflammatory response; neutrophil activation; neutrophil chemotaxis; neutrophil degranulation; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of cell proliferation; receptor internalization; signal transduction
Reference #:  P25025 (UniProtKB)
Alt. Names/Synonyms: C-X-C chemokine receptor type 2; CD182; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
Gene Symbols: CXCR2
Molecular weight: 40,759 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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