a protein kinase of the CDK family. Forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. A component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. Transcriptional elongation factor and cofactor for HIV Tat protein; RNAi blocks HIV replication, and inhibitors also block varicella zoster replication. Mediates signals leading to cardiac hypertrophy. Inhibitor: Flavopiridol. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK9 subfamily; CDK9 subfamily; CMGC group; Cell cycle regulation; EC 184.108.40.206; EC 220.127.116.11; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; DNA binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; snRNA binding; transcription factor binding; transferase activity
Biological Process: cellular response to DNA damage stimulus; DNA repair; phosphorylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of DNA repair; regulation of histone modification; regulation of muscle cell differentiation; regulation of transcription, DNA-templated; replication fork processing; transcription elongation from RNA polymerase II promoter; transcription, DNA-dependent