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CDK9 a protein kinase of the CDK family. Forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. A component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. Transcriptional elongation factor and cofactor for HIV Tat protein; RNAi blocks HIV replication, and inhibitors also block varicella zoster replication. Mediates signals leading to cardiac hypertrophy. Inhibitor: Flavopiridol. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK9 subfamily; CDK9 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2|2 B
Cellular Component: chromosome; cytoplasm; membrane; nucleoplasm; nucleus; PML body; transcription elongation factor complex; transcription elongation factor complex b
Molecular Function: ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; DNA binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; snRNA binding; transcription factor binding; transferase activity
Biological Process: cellular response to DNA damage stimulus; DNA repair; phosphorylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of DNA repair; regulation of histone modification; regulation of muscle cell differentiation; regulation of transcription, DNA-templated; replication fork processing; transcription elongation from RNA polymerase II promoter; transcription, DNA-dependent
Reference #:  Q99J95 (UniProtKB)
Alt. Names/Synonyms: Cdk9; Cell division protein kinase 9; Cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); OTTMUSP00000013406; PITALRE; PTEFB
Gene Symbols: Cdk9
Molecular weight: 42,762 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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