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IKKB a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: EC; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8|8 A2
Cellular Component: cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; intracellular membrane-bound organelle; membrane; nucleus
Molecular Function: ATP binding; identical protein binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; transferase activity
Biological Process: anatomical structure morphogenesis; B cell homeostasis; cellular response to tumor necrosis factor; cortical actin cytoskeleton organization and biogenesis; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; inflammatory response; innate immune response; neuron projection development; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cation channel activity; positive regulation of cell proliferation; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of sodium ion transport; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; protein localization to plasma membrane; regulation of phosphorylation; tumor necrosis factor-mediated signaling pathway
Reference #:  O88351 (UniProtKB)
Alt. Names/Synonyms: AI132552; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkappaB kinase; IkBKB; IKK-2; IKK-B; IKK-beta; IKK2; IKK[b]; Ikkb; IKKbeta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; OTTMUSP00000022456
Gene Symbols: Ikbkb
Molecular weight: 86,690 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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