a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Cellular Component: cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; intracellular membrane-bound organelle; membrane; nucleus
Molecular Function: ATP binding; identical protein binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; transferase activity
Biological Process: anatomical structure morphogenesis; B cell homeostasis; cellular response to tumor necrosis factor; cortical actin cytoskeleton organization and biogenesis; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; inflammatory response; innate immune response; neuron projection development; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cation channel activity; positive regulation of cell proliferation; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of sodium ion transport; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; protein localization to plasma membrane; regulation of phosphorylation; tumor necrosis factor-mediated signaling pathway