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Protein Page:
IKKB

Overview
IKKB a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.10; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; membrane raft; nucleus
Molecular Function: ATP binding; identical protein binding; IkappaB kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: anatomical structure morphogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular response to tumor necrosis factor; cortical actin cytoskeleton organization and biogenesis; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; inflammatory response; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of apoptosis; nucleotide-binding oligomerization domain containing signaling pathway; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; protein localization to plasma membrane; regulation of phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency 15
Reference #:  O14920 (UniProtKB)
Alt. Names/Synonyms: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkappaB kinase; IKBKB; IKK-B; IKK-beta; IKK2; IKKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta
Gene Symbols: IKBKB
Molecular weight: 86,564 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IKKB

Protein Structure Not Found.
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