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CDC6 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleolus; nucleoplasm; nucleus; spindle midzone; spindle pole
Molecular Function: kinase binding; nucleotide binding; protein binding
Biological Process: DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cytokinesis; regulation of cyclin-dependent protein kinase activity; regulation of mitotic metaphase/anaphase transition; traversing start control point of mitotic cell cycle
Disease: Meier-gorlin Syndrome 5
Reference #:  Q99741 (UniProtKB)
Alt. Names/Synonyms: CDC18 (cell division cycle 18, S.pombe, homolog)-like; Cdc18-related protein; CDC18L; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; p62(cdc6)
Gene Symbols: CDC6
Molecular weight: 62,720 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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