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ATP7B Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Monomer. Interacts with COMMD1/MURR1. Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle
Chromosomal Location of Human Ortholog: 13q14.3
Cellular Component: basolateral plasma membrane; cytoplasmic vesicle; Golgi apparatus; Golgi membrane; integral component of plasma membrane; late endosome; membrane; mitochondrion; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane
Molecular Function: ATP binding; copper ion binding; copper ion transmembrane transporter activity; copper-exporting ATPase activity; copper-transporting ATPase activity; protein binding
Biological Process: cellular copper ion homeostasis; cellular zinc ion homeostasis; copper ion export; copper ion import; copper ion transport; intracellular copper ion transport; lactation; response to copper ion; sequestering of calcium ion
Disease: Wilson Disease
Reference #:  P35670 (UniProtKB)
Alt. Names/Synonyms: ATP7B; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; Copper pump 2; Copper-transporting ATPase 2; PWD; WC1; WD; Wilson disease-associated protein; WND; WND/140 kDa
Gene Symbols: ATP7B
Molecular weight: 157,263 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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