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CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: adherens junction; basolateral plasma membrane; beta-catenin destruction complex; catenin complex; cell cortex; cell junction; cell-cell adherens junction; centrosome; cytoplasm; cytosol; focal adhesion; intercellular junction; intracellular; lateral plasma membrane; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; synapse; transcription factor complex
Molecular Function: alpha-catenin binding; cadherin binding; enzyme binding; estrogen receptor binding; kinase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein phosphatase binding; SMAD binding; transcription coactivator activity; transcription factor binding
Biological Process: cell adhesion; cell-cell adhesion; epithelial to mesenchymal transition; hair cell differentiation; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of mitotic cell cycle, embryonic; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; patterning of blood vessels; positive regulation of apoptosis; positive regulation of histone H3-K4 methylation; positive regulation of interferon type I production; positive regulation of muscle cell differentiation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptosis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of angiogenesis; regulation of centriole-centriole cohesion; regulation of fibroblast proliferation; regulation of neurogenesis; regulation of smooth muscle cell proliferation; response to drug; response to estradiol stimulus; stem cell maintenance; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway
Disease: Colorectal Cancer; Exudative Vitreoretinopathy 7; Hepatocellular Carcinoma; Medulloblastoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Pilomatrixoma
Reference #:  P35222 (UniProtKB)
Alt. Names/Synonyms: Beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin beta-1; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923
Gene Symbols: CTNNB1
Molecular weight: 85,497 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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