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Protein Page:

Rb retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 13q14.2
Cellular Component: chromatin; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex; transcription elongation factor complex b
Molecular Function: androgen receptor binding; DNA binding; DNA binding transcription factor activity; identical protein binding; kinase binding; phosphoprotein binding; protein binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
Biological Process: androgen receptor signaling pathway; cell cycle arrest; cell cycle checkpoint; cell division; cell morphogenesis involved in neuron differentiation; cellular response to xenobiotic stimulus; chromatin remodeling; covalent chromatin modification; enucleate erythrocyte differentiation; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; gut development; maintenance of mitotic sister chromatid cohesion; mitotic cell cycle checkpoint; myoblast differentiation; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of protein kinase activity; negative regulation of smoothened signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; neuron apoptosis; neuron maturation; neuron projection development; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; positive regulation of transcription, DNA-templated; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell growth; regulation of centromere complex assembly; regulation of cohesin loading; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription, DNA-templated; sister chromatid biorientation; striated muscle cell differentiation; tissue homeostasis; transcription, DNA-dependent; viral process
Disease: Bladder Cancer; Osteogenic Sarcoma; Retinoblastoma; Small Cell Cancer Of The Lung
Reference #:  P06400 (UniProtKB)
Alt. Names/Synonyms: OSRC; p105-Rb; pp110; pRb; Rb; RB1; retinoblastoma 1; retinoblastoma suspectibility protein; Retinoblastoma-associated protein
Gene Symbols: RB1
Molecular weight: 106,159 Da
Basal Isoelectric point: 8.13  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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