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p57Kip2 Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cytoplasm; nucleus
Molecular Function: cyclin-dependent protein serine/threonine kinase inhibitor activity; protein binding; protein kinase inhibitor activity
Biological Process: adrenal gland development; aging; camera-type eye development; cell cycle arrest; kidney development; multicellular organism growth; myeloid cell differentiation; negative regulation of epithelial cell proliferation; negative regulation of kinase activity; negative regulation of phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron maturation; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of exit from mitosis; skeletal system development; uterus development
Disease: Beckwith-wiedemann Syndrome; Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Reference #:  P49918 (UniProtKB)
Alt. Names/Synonyms: BWCR; BWS; CDKN1C; CDN1C; Cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); Cyclin-dependent kinase inhibitor p57; KIP2; p57; p57Kip2; WBS
Gene Symbols: CDKN1C
Molecular weight: 32,177 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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