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Btk a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: X E3|X 56.18 cM
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; lipid raft; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: identical protein binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein-tyrosine kinase activity; receptor binding
Biological Process: B cell affinity maturation; cell maturation; histamine secretion by mast cell; I-kappaB kinase/NF-kappaB cascade; innate immune response; negative regulation of B cell proliferation; negative regulation of cytokine production; peptidyl-tyrosine phosphorylation; positive regulation of type I hypersensitivity; positive regulation of type III hypersensitivity; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to organic substance; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P35991 (UniProtKB)
Alt. Names/Synonyms: Agammaglobulinaemia tyrosine kinase; AI528679; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; Btk; Kinase EMB; OTTMUSP00000020834; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); X-linked immune deficiency; xid
Gene Symbols: Btk
Molecular weight: 76,437 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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