an adapter protein which binds ubiquitin, shuttling proteins to the proteasome. Co-localizes along with the E3 ubiquitin ligase, TRAF6, to aggregates from Alzheimer's disease brains but not in control brain. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Forms ternary complexes with PKCZ and Kv-beta2 or PKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Interacts with EBI3, LCK, RASA1, PKCZ , PKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MEK5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63- polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MEK5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system
Cellular Component: autophagic vacuole; cytoplasm; cytosol; endoplasmic reticulum; inclusion body; intracellular membrane-bound organelle; late endosome; nucleoplasm; PML body
Molecular Function: enzyme binding; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein serine/threonine kinase activity; receptor tyrosine kinase binding; SH2 domain binding; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process: apoptosis; autophagy; cell differentiation; endosomal transport; endosome organization and biogenesis; immune system process; macroautophagy; macromitophagy; mitochondrion degradation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; protein heterooligomerization; protein localization; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of Ras protein signal transduction; response to stress; ubiquitin-dependent protein catabolic process