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SQSTM1 an adapter protein which binds ubiquitin, shuttling proteins to the proteasome. Co-localizes along with the E3 ubiquitin ligase, TRAF6, to aggregates from Alzheimer's disease brains but not in control brain. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Forms ternary complexes with PKCZ and Kv-beta2 or PKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Interacts with EBI3, LCK, RASA1, PKCZ , PKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MEK5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63- polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MEK5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: autophagic vacuole; cytoplasm; cytosol; endoplasmic reticulum; inclusion body; intracellular membrane-bound organelle; late endosome; nucleoplasm; PML body
Molecular Function: enzyme binding; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein serine/threonine kinase activity; receptor tyrosine kinase binding; SH2 domain binding; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process: apoptosis; autophagy; cell differentiation; endosomal transport; endosome organization and biogenesis; immune system process; macroautophagy; macromitophagy; mitochondrion degradation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; protein heterooligomerization; protein localization; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of Ras protein signal transduction; response to stress; ubiquitin-dependent protein catabolic process
Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 3; Myopathy, Distal, With Rimmed Vacuoles; Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy, Childhood-onset; Paget Disease Of Bone; Paget Disease Of Bone 3
Reference #:  Q13501 (UniProtKB)
Alt. Names/Synonyms: A170; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; ORCA; OSIL; oxidative stress induced like; p60; p62; p62B; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; sequestosome 1; Sequestosome-1; SQSTM; SQSTM1; Ubiquitin-binding protein p62; ZIP3
Gene Symbols: SQSTM1
Molecular weight: 47,687 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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