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Protein Page:
COPA

Overview
COPA The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 1 H3|1 79.54 cM
Cellular Component: COPI vesicle coat; cytoplasm; extracellular space; membrane
Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; pancreatic juice secretion; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q8CIE6 (UniProtKB)
Alt. Names/Synonyms: alpha-coat protein; alpha-COP; AU040324; coatomer protein complex subunit alpha; coatomer subunit alpha; Copa; xenin
Gene Symbols: Copa
Molecular weight: 138,432 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
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COPA

Protein Structure Not Found.
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