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GART a highly conserved trifunctional enzyme. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. Inhibition of the de novo purine synthesis by folate analogs blocks the p53-dependent G1 checkpoint in human carcinoma cell lines. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; EC; EC; Ligase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: cytosol
Molecular Function: ATP binding; metal ion binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity
Biological Process: cerebellum development; cerebral cortex development; de novo'IMP biosynthetic process; glycine metabolic process; purine nucleobase biosynthetic process; purine ribonucleoside monophosphate biosynthetic process; response to inorganic substance; response to organic substance; tetrahydrofolate biosynthetic process
Reference #:  P22102 (UniProtKB)
Alt. Names/Synonyms: 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; GARTF; Glycinamide ribonucleotide synthetase; MGC47764; PAIS; PGFT; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylamine--glycine ligase; Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylglycinamide formyltransferase; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; Phosphoribosylglycinamide synthetase; PRGS; PUR2; Trifunctional purine biosynthetic protein adenosine-3
Gene Symbols: GART
Molecular weight: 107,767 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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