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MIF a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC; EC; Isomerase
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: cell surface; cytosol; extracellular region; nucleoplasm; vesicle
Molecular Function: chemoattractant activity; cytokine activity; dopachrome isomerase activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; phenylpyruvate tautomerase activity; protein binding; receptor binding
Biological Process: carboxylic acid metabolic process; cell proliferation; cell surface receptor linked signal transduction; leukocyte migration; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; neutrophil degranulation; positive regulation of B cell proliferation; positive regulation of cytokine secretion; positive regulation of fibroblast proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; prostaglandin biosynthetic process
Disease: Rheumatoid Arthritis, Systemic Juvenile
Reference #:  P14174 (UniProtKB)
Alt. Names/Synonyms: GIF; GLIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MIF; MMIF; Phenylpyruvate tautomerase
Gene Symbols: MIF
Molecular weight: 12,476 Da
Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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