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DRPLA a protein that interacts with the E3 ubiquitin-protein ligase WWP1 and WWP2. May be involved in the third step of ubiquitin conjugation. Relatively high levels in the brain, ovary, testis and prostate. Lower levels in the liver, thymus and leukocytes. Defects are the cause of the neurodegenerative disorders dentatorubral-pallidoluysian atrophy (DRPLA) and Haw River syndrome (HRS). Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytoplasm; nuclear matrix; nucleoplasm; nucleus
Molecular Function: protein binding; protein domain specific binding; transcription corepressor activity
Biological Process: central nervous system development; negative regulation of transcription from RNA polymerase II promoter; neuron apoptosis
Disease: Dentatorubral-pallidoluysian Atrophy
Reference #:  P54259 (UniProtKB)
Alt. Names/Synonyms: ATN1; atrophin 1; Atrophin-1; B37; D12S755E; Dentatorubral-pallidoluysian atrophy protein; DRPLA; HRS; NOD
Gene Symbols: ATN1
Molecular weight: 125,414 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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