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PEA-15 an ubiquitously expressed anti-apoptotic protein. Inhibits both Fas- and Tnfrsf1a/Tnfr1-mediated caspase-8 activity and apoptosis. Interacts with CASP8/FLICE and FADD. Regulates glucose transport by controlling both the content of GLUT1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of GLUT4 from the cell interior to the surface. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: cytosol; microtubule associated complex; nucleus
Molecular Function: protein binding
Biological Process: activation of MAPK activity; apoptosis; carbohydrate transport; DNA damage checkpoint; MAPK cascade; negative regulation of glucose import; response to morphine; transport
Reference #:  Q15121 (UniProtKB)
Alt. Names/Synonyms: 15 kDa phosphoprotein enriched in astrocytes; Astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT-1 oncogene; HUMMAT1H; MAT1; MAT1H; PEA-15; PEA15; PED; phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes, 15kD; Phosphoprotein enriched in diabetes
Gene Symbols: PEA15
Molecular weight: 15,040 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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