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IP3R1 a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p26.1
Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; platelet dense granule membrane
Molecular Function: calcium channel inhibitor activity; calcium ion binding; calcium ion transmembrane transporter activity; calcium-release channel activity; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; phosphoinositide binding; protein binding
Biological Process: negative regulation of calcium-mediated signaling; platelet activation; regulation of autophagy; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia
Disease: Aniridia, Cerebellar Ataxia, And Mental Retardation
Reference #:  Q14643 (UniProtKB)
Alt. Names/Synonyms: DKFZp313E1334; DKFZp313N1434; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; SCA15; SCA16; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene Symbols: ITPR1
Molecular weight: 313,929 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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