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Protein Page:

MPL a hematopoietic receptor for thrombopoietin. Thrombopoietin is the major regulator of megakaryocytopoiesis and platelet formation. Dimerizes upon binding of thrombopoietin, leading to its phosphorylation and activation of JAKs and STATs. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: cell surface; Golgi apparatus; integral component of plasma membrane; plasma membrane
Molecular Function: protein binding; transmembrane receptor activity
Biological Process: cell proliferation; cell surface receptor signaling pathway
Disease: Amegakaryocytic Thrombocytopenia, Congenital; Myelofibrosis; Thrombocythemia 2
Reference #:  P40238 (UniProtKB)
Alt. Names/Synonyms: C-MPL; CD110; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin receptor; TPO-R; TPOR
Gene Symbols: MPL
Molecular weight: 71,245 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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