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GABRB1 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: cell junction; cytoplasm; dendrite; integral component of plasma membrane; nuclear envelope; plasma membrane; postsynaptic membrane
Molecular Function: GABA receptor binding; GABA-A receptor activity; GABA-gated chloride ion channel activity; ligand-gated ion channel activity
Biological Process: central nervous system neuron development; gamma-aminobutyric acid signaling pathway; ion transport; ovulation cycle; response to progesterone; response to toxin; signal transduction; transport
Disease: Epileptic Encephalopathy, Early Infantile, 45
Reference #:  P18505 (UniProtKB)
Alt. Names/Synonyms: GABA(A) receptor subunit beta-1; GABRB1; gamma-aminobutyric acid (GABA) A receptor, beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GBRB1
Gene Symbols: GABRB1
Molecular weight: 54,235 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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