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APC a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 18 B1|18 18.53 cM
Cellular Component: axon; beta-catenin destruction complex; catenin complex; cell cortex; cell projection; cell projection membrane; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; dendrite; growth cone; kinetochore; lamellipodium; lateral plasma membrane; microtubule; neuron projection; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; synapse; tight junction
Molecular Function: beta-catenin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein complex binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process: anterior/posterior pattern formation; axis specification; axonogenesis; cell cycle arrest; cell migration; chromosome organization and biogenesis; cytokinesis after mitosis; cytoplasmic microtubule organization and biogenesis; dorsal/ventral pattern formation; establishment and/or maintenance of cell polarity; hair follicle development; insulin receptor signaling pathway; kidney development; mitotic cell cycle spindle assembly checkpoint; mitotic metaphase/anaphase transition; muscle maintenance; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of epithelial cell proliferation; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt receptor signaling pathway; neurite development; pattern specification process; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of epithelial cell differentiation; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of pseudopodium formation; protein complex assembly; protein homooligomerization; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; response to DNA damage stimulus; retina development in camera-type eye; skin development; somatic stem cell maintenance; stem cell maintenance; T cell differentiation in the thymus; thymus development; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Reference #:  Q61315 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli; Adenomatous polyposis coli protein; AI047805; Apc; AU020952; AW124434; CC1; mAPC; Min; multiple intestinal neoplasia; Protein APC
Gene Symbols: Apc
Molecular weight: 311,089 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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