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APC a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 5q22.2
Cellular Component: beta-catenin destruction complex; catenin complex; cell-cell adherens junction; centrosome; cytoplasm; cytosol; kinetochore; lamellipodium; lateral plasma membrane; microtubule; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; tight junction
Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process: cell cycle arrest; cell migration; cytokinesis after mitosis; insulin receptor signaling pathway; mitotic cell cycle spindle assembly checkpoint; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of microtubule depolymerization; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of protein catabolic process; positive regulation of pseudopodium formation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein deubiquitination; protein homooligomerization; regulation of attachment of spindle microtubules to kinetochore; regulation of microtubule-based process; response to DNA damage stimulus; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Disease: Colorectal Cancer; Desmoid Disease, Hereditary; Familial Adenomatous Polyposis 1; Gastric Cancer; Hepatocellular Carcinoma
Reference #:  P25054 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; Adenomatous polyposis coli protein; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5; DP3; GS; Protein APC
Gene Symbols: APC
Molecular weight: 311,646 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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