eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GEF; GEF, misc.; RNA-binding; Translation
Molecular Function: ATP binding; GTP binding; guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity
Biological Process: cellular response to stimulus; central nervous system development; myelination; oligodendrocyte development; ovarian follicle development; regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation