a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Note: This description may include information from UniProtKB.
Cellular Component: cell junction; cell soma; cytosol; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; intrinsic component of plasma membrane; plasma membrane; postsynaptic membrane
Molecular Function: ATP binding; calcium channel activity; calcium-release channel activity; calmodulin binding; chloride channel regulator activity; excitatory extracellular ligand-gated ion channel activity; extracellular ligand-gated ion channel activity; identical protein binding; metal ion binding; phosphatidylinositol binding; phosphoprotein binding; transmembrane receptor activity
Biological Process: behavioral response to pain; calcium ion import across plasma membrane; cell surface receptor signaling pathway; cellular response to acidic pH; cellular response to alkaloid; cellular response to ATP; cellular response to heat; cellular response to temperature stimulus; cellular response to tumor necrosis factor; chemosensory behavior; detection of chemical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; detection of temperature stimulus involved in thermoception; diet induced thermogenesis; excitatory postsynaptic potential; fever; glutamate secretion; lipid metabolic process; microglial cell activation; negative regulation of establishment of blood-brain barrier; negative regulation of transcription from RNA polymerase II promoter; peptide secretion; positive regulation of apoptosis; positive regulation of nitric oxide biosynthetic process; protein homotetramerization; regulation of molecular function; release of sequestered calcium ion into cytosol; response to capsazepine; response to peptide hormone; sensory perception of mechanical stimulus; smooth muscle contraction involved in micturition; thermoception; transport