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LRRK1 a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LRRK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: cytoplasm; cytosol; mitochondrion
Molecular Function: identical protein binding; protein binding; protein serine/threonine kinase activity; signal transducer activity
Reference #:  Q38SD2 (UniProtKB)
Alt. Names/Synonyms: FLJ23119; FLJ27465; KIAA1790; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1; RIPK6; Roco1
Gene Symbols: LRRK1
Molecular weight: 225,393 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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