Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CHKB Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, other; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol
Molecular Function: ATP binding; choline kinase activity; ethanolamine kinase activity
Biological Process: CDP-choline pathway; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphorylation
Disease: Muscular Dystrophy, Congenital, Megaconial Type
Reference #:  Q9Y259 (UniProtKB)
Alt. Names/Synonyms: CHETK; CHKB; CHKL; Choline kinase beta; Choline kinase-like protein; Choline/ethanolamine kinase; choline/ethanolamine kinase beta; CK; CKB; CKEKB; EK; EKB; Ethanolamine kinase; Ethanolamine kinase beta
Gene Symbols: CHKB
Molecular weight: 45,271 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB