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RASA1 a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 5q14.3
Cellular Component: cytoplasm; cytosol; ruffle
Molecular Function: GTPase activator activity; GTPase activity; GTPase binding; phosphotyrosine binding; potassium channel inhibitor activity; protein binding; receptor binding
Biological Process: blood vessel morphogenesis; embryonic development; ephrin receptor signaling pathway; MAPK cascade; mitotic cytokinesis; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptosis; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of cell shape; regulation of RNA metabolic process; signal transduction; vasculogenesis
Disease: Basal Cell Carcinoma, Susceptibility To, 1; Capillary Malformation-arteriovenous Malformation; Parkes Weber Syndrome
Reference #:  P20936 (UniProtKB)
Alt. Names/Synonyms: CM-AVM; CMAVM; DKFZp434N071; GAP; GTPase-activating protein; p120GAP; p120RASGAP; PKWS; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RASA; RASA1; RasGAP; triphosphatase-activating protein
Gene Symbols: RASA1
Molecular weight: 116,403 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  T Cell Receptor Signaling
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