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GPR56 Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: integral component of membrane; integral component of plasma membrane; intracellular; membrane raft
Molecular Function: collagen binding; extracellular matrix binding; G-protein coupled receptor activity; heparin binding
Biological Process: angiogenesis; brain development; cell adhesion; cell migration; cell surface receptor signaling pathway; cell-cell signaling; cerebral cortex radial glia guided migration; cerebral cortex regionalization; G-protein coupled receptor signaling pathway; layer formation in cerebral cortex; negative regulation of cell proliferation; positive regulation of cell adhesion; positive regulation of Rho protein signal transduction; Rho protein signal transduction
Disease: Polymicrogyria, Bilateral Frontoparietal; Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive
Reference #:  Q9Y653 (UniProtKB)
Alt. Names/Synonyms: 7-transmembrane protein with no EGF-like N-terminal domains-1; BFPP; DKFZp781L1398; EGF-TM7-like; G protein-coupled receptor 56; G-protein coupled receptor 56; GPR56; Protein TM7XN1; TM7LN4; TM7XN1
Gene Symbols: ADGRG1
Molecular weight: 77,738 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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