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Protein Page:
HNF4 alpha

HNF4 alpha a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA binding transcription factor activity; fatty acid binding; ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; receptor binding; steroid hormone receptor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process: blood coagulation; glucose homeostasis; intracellular receptor signaling pathway; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell proliferation; ornithine metabolic process; phospholipid homeostasis; positive regulation of cholesterol homeostasis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription from RNA polymerase II promoter; response to glucose stimulus; sex differentiation; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; triglyceride homeostasis; xenobiotic metabolic process
Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1
Reference #:  P41235 (UniProtKB)
Alt. Names/Synonyms: FLJ39654; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4alpha10/11/12; MODY; MODY1; NR2A1; NR2A21; Nuclear receptor subfamily 2 group A member 1; TCF; TCF-14; TCF14; Transcription factor 14; Transcription factor HNF-4; transcription factor-14
Gene Symbols: HNF4A
Molecular weight: 52,785 Da
Basal Isoelectric point: 7.15  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  AMPK Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HNF4 alpha

Protein Structure Not Found.
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