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TRPA1 Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q21.11
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: calcium channel activity; calcium-release channel activity; channel activity
Biological Process: ion transport; protein homotetramerization; response to organic substance; sensory perception of pain
Disease: Episodic Pain Syndrome, Familial, 1
Reference #:  O75762 (UniProtKB)
Alt. Names/Synonyms: ANKTM1; ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel, subfamily A, member 1; TRPA1
Gene Symbols: TRPA1
Molecular weight: 127,501 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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