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CX3CL1 The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: cell surface; extracellular region; extracellular space; integral component of membrane; plasma membrane
Molecular Function: CCR chemokine receptor binding; chemokine activity; CX3C chemokine receptor binding; integrin binding; protein binding; receptor binding
Biological Process: angiogenesis involved in wound healing; cell adhesion; chemotaxis; cytokine-mediated signaling pathway; defense response; G-protein coupled receptor signaling pathway; immune response; integrin activation; leukocyte adhesive activation; leukocyte chemotaxis; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; macrophage chemotaxis; monocyte chemotaxis; negative regulation of cell migration; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of transforming growth factor beta1 production
Reference #:  P78423 (UniProtKB)
Alt. Names/Synonyms: ABCD-3; C-X3-C motif chemokine 1; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; Small-inducible cytokine D1; X3CL1
Gene Symbols: CX3CL1
Molecular weight: 42,203 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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