Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CaR a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q13.33-q21.1
Cellular Component: apical plasma membrane; axon; axon terminus; basolateral plasma membrane; cell soma; cell surface; cytoplasm; integral component of plasma membrane; nucleus; plasma membrane
Molecular Function: amino acid binding; calcium ion binding; drug binding; G-protein coupled receptor activity; integrin binding; ion channel binding; magnesium ion binding; phosphoinositide phospholipase C activity; polyamine binding; protein binding; protein homodimerization activity; protein kinase binding
Biological Process: anatomical structure morphogenesis; apoptosis; branching morphogenesis of a tube; cellular calcium ion homeostasis; cellular response to glucose stimulus; cellular response to hypoxia; cellular response to low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to vitamin D; chemosensory behavior; detection of calcium ion; G-protein coupled receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; JNK cascade; ossification; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of ATPase activity; positive regulation of calcium ion import; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of insulin secretion; positive regulation of positive chemotaxis; positive regulation of vasoconstriction; response to fibroblast growth factor; vasodilation
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I
Reference #:  P41180 (UniProtKB)
Alt. Names/Synonyms: calcium-sensing receptor; CAR; CASR; EIG8; Extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; PCAR1
Gene Symbols: CASR
Molecular weight: 120,675 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene