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RORC Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component: nuclear body; nucleus
Molecular Function: DNA binding; oxysterol binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: alpha-beta T cell differentiation; cell differentiation; circadian regulation of gene expression; interleukin-17 production; lymph node development; mucosal-associated lymphoid tissue development; Peyer's patch development; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of fat cell differentiation; regulation of gamma-delta T cell differentiation; regulation of steroid metabolic process; regulation of transcription, DNA-dependent; T cell differentiation in the thymus; T-helper cell differentiation; xenobiotic metabolic process
Reference #:  P51450 (UniProtKB)
Alt. Names/Synonyms: Nr1f3; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; OTTMUSP00000025973; RAR-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; Rorc; Rorg; RORgamma; Thor; Thymus orphan receptor; TOR
Gene Symbols: Rorc
Molecular weight: 58,117 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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