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CATSPER1 Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7). An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: plasma membrane
Molecular Function: high voltage-gated calcium channel activity; protein binding
Biological Process: response to progesterone stimulus; sperm-egg recognition
Disease: Spermatogenic Failure 7
Reference #:  Q8NEC5 (UniProtKB)
Alt. Names/Synonyms: Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CATSPER; CATSPER1; CTSR1; hCatSper; MGC33335; MGC33368; sperm ion channel; sperm-associated cation channel 1
Gene Symbols: CATSPER1
Molecular weight: 90,091 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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