the enzyme 3-beta-hydroxysterol delta-24-reductase (DHCR24), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. Overexpressed in the adenoma tissue of patients with Cushing's syndrome. May be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; Golgi apparatus; integral component of membrane; membrane; nucleus
Molecular Function: delta24(24-1) sterol reductase activity; delta24-sterol reductase activity; enzyme binding; FAD binding; oxidoreductase activity; oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; peptide antigen binding
Biological Process: amyloid precursor protein catabolic process; cholesterol biosynthetic process; cholesterol metabolic process; lipid metabolic process; male genitalia development; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; plasminogen activation; protein localization; Ras protein signal transduction; skin development; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process; sterol metabolic process; tissue development