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Protein Page:
NuMA-1

Overview
NuMA-1 a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: apical part of cell; cell cortex; cell soma; centrosome; chromosome; cytoplasmic microtubule bundle; cytosol; dendrite; extracellular exosome; extrinsic component of plasma membrane; Golgi membrane; lateral plasma membrane; microtubule minus-end; mitotic spindle midzone; nuclear matrix; nucleoplasm; nucleus; protein complex; spindle; spindle microtubule; spindle pole; spindle pole centrosome
Molecular Function: microtubule binding; microtubule minus-end binding; microtubule plus-end binding; phosphatidylinositol binding; protein binding; protein C-terminus binding; protein complex binding; protein domain specific binding; structural molecule activity; tubulin binding
Biological Process: anastral spindle assembly; astral microtubule organization; cell division; chromosome segregation; establishment of mitotic spindle orientation; meiotic cell cycle; microtubule bundle formation; nucleus organization; positive regulation of BMP signaling pathway; positive regulation of chromosome segregation; positive regulation of hair follicle development; positive regulation of intracellular transport; positive regulation of keratinocyte differentiation; positive regulation of microtubule polymerization; positive regulation of protein localization to cell cortex; positive regulation of protein localization to spindle pole body; regulation of metaphase plate congression
Disease: Acute Promyelocytic Leukemia
Reference #:  Q14980 (UniProtKB)
Alt. Names/Synonyms: centrophilin stabilizes mitotic spindle in mitotic cells; Nuclear mitotic apparatus protein 1; NUMA; NuMA protein; NUMA1; SP-H antigen; structural nuclear protein
Gene Symbols: NUMA1
Molecular weight: 238,260 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NuMA-1

Protein Structure Not Found.
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