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Rab7 a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: cytosol; endosome membrane; late endosome; late endosome membrane; lipid particle; lysosomal membrane; lysosome; phagocytic vesicle; plasma membrane; retromer complex; secretory granule membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagic vacuole formation; early endosome to late endosome transport; endocytosis; endosome to lysosome transport; epidermal growth factor ligand processing; neutrophil degranulation; positive regulation of protein catabolic process; positive regulation of viral reproduction; protein targeting to lysosome; protein to membrane docking; protein transport; release of virus from host; retrograde transport, endosome to Golgi
Disease: Charcot-marie-tooth Disease, Axonal, Type 2b
Reference #:  P51149 (UniProtKB)
Alt. Names/Synonyms: FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a
Gene Symbols: RAB7A
Molecular weight: 23,490 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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