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G-alpha(q) a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of Human Ortholog: 9q21.2
Cellular Component: cytoplasm; heterotrimeric G-protein complex; lysosomal membrane; photoreceptor outer segment; plasma membrane
Molecular Function: G-protein beta/gamma-subunit binding; GTPase activator activity; GTPase activity; protein binding; signal transducer activity; type 2A serotonin receptor binding
Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; negative regulation of protein kinase activity; phospholipase C activation; phototransduction, visible light; platelet activation; protein stabilization; regulation of action potential
Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome
Reference #:  P50148 (UniProtKB)
Alt. Names/Synonyms: G-ALPHA-q; GAQ; GNAQ; guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha
Gene Symbols: GNAQ
Molecular weight: 42,142 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  mTOR Signaling  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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