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HSD3B2 protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Endoplasmic reticulum; Isomerase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p12
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial membrane; smooth endoplasmic reticulum membrane
Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; cholesterol dehydrogenase activity; steroid delta-isomerase activity
Biological Process: androgen biosynthetic process; glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process
Disease: 3-beta-hydroxysteroid Dehydrogenase, Type Ii, Deficiency Of
Reference #:  P26439 (UniProtKB)
Alt. Names/Synonyms: 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3BHS2; delta 5-delta 4-isomerase type II; Delta-5-3-ketosteroid isomerase; HSD3B; HSD3B2; HSDB; HSDB3B; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Progesterone reductase; SDR11E2; short chain dehydrogenase/reductase family 11E, member 2; Steroid Delta-isomerase
Gene Symbols: HSD3B2
Molecular weight: 42,052 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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