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FIP1L1 a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is the cause of some cases of hypereosinophilic syndrome (HES), a disorder characterized by overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm
Molecular Function: protein binding; RNA binding
Biological Process: mRNA 3'-end processing; mRNA export from nucleus; mRNA polyadenylation; mRNA splicing, via spliceosome; pre-mRNA cleavage required for polyadenylation; termination of RNA polymerase II transcription
Disease: Hypereosinophilic Syndrome, Idiopathic
Reference #:  Q6UN15 (UniProtKB)
Alt. Names/Synonyms: DKFZp586K0717; Factor interacting with PAP; FIP1; FIP1 like 1; FIP1 like 1 (S. cerevisiae); FIP1-like 1 protein; FIP1L1; FLJ33619; hFip1; Pre-mRNA 3'-end-processing factor FIP1; Rearranged in hypereosinophilia; RHE
Gene Symbols: FIP1L1
Molecular weight: 66,526 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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