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DCP1A a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; membrane; nucleus; P-body
Molecular Function: enzyme activator activity; enzyme regulator activity; hydrolase activity; identical protein binding; kinesin binding; mRNA binding; protein binding
Biological Process: deadenylation-dependent decapping; deadenylation-independent decapping of nuclear-transcribed mRNA; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; regulation of mRNA stability
Reference #:  Q9NPI6 (UniProtKB)
Alt. Names/Synonyms: DCP1 decapping enzyme homolog A (S. cerevisiae); DCP1A; decapping enzyme hDcp1a; FLJ21691; HSA275986; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; Transcription factor SMIF
Gene Symbols: DCP1A
Molecular weight: 63,309 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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