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PHF21A Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: DNA repair complex; histone deacetylase complex; nucleoplasm
Molecular Function: chromatin binding; histone binding; histone deacetylase activity; metal ion binding; protein binding; transcription cofactor activity
Biological Process: blood coagulation; histone deacetylation; regulation of transcription, DNA-templated; transcription, DNA-dependent
Reference #:  Q96BD5 (UniProtKB)
Alt. Names/Synonyms: BHC80; BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A; PHD finger protein 21A; PHF21A
Gene Symbols: PHF21A
Molecular weight: 74,854 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
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