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RXRB Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Expressed in a variety of tumor cell lines. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 6p21.32
Cellular Component: nucleoplasm; nucleus
Molecular Function: 9-cis retinoic acid receptor activity; DNA binding transcription factor activity; ligand-dependent nuclear receptor activity; protein binding; steroid hormone receptor activity; transcription coactivator activity; zinc ion binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
Reference #:  P28702 (UniProtKB)
Alt. Names/Synonyms: DAUDI6; H-2RIIBP; MGC1831; MHC class I promoter binding protein; NR2B2; Nuclear receptor subfamily 2 group B member 2; RCoR-1; Retinoic acid receptor RXR-beta; Retinoid X receptor beta; retinoid X receptor, beta; RXRB
Gene Symbols: RXRB
Molecular weight: 56,922 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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